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At that time, a slow steroid taper is initiated if the initial prednisone dosage was 15 or 20 mg per day, based on the individual patient's medical history and the degree of prednisone sensitivity. This taper can be as short as a few months, or as long as many years. During prednisone tapers, patients who normally take 15 or 20 mg per day will no longer require 10 mg daily. Patients have an opportunity to switch to 10 mg after one year of regular dosage, or for another year after a second prednisone taper. In individuals who are able to tolerate normal therapeutic dose for longer, 10 mg for five days per week should be the maximum prednisone dosage prescribed for ten consecutive weeks. Prednisone should be prescribed during the initial months of pregnancy and after the onset of labor. In situations in which a woman has been on chronic prednisone therapy to maintain pregnancy, her physician should discuss prescribing prednisone tapers to avoid an increasing risk for spontaneous abortion. Women should be warned about the cumulative effect of chronic therapy. Although prednisone tapers can produce significant weight loss, prolonged therapy could produce profound weight loss as well. As prednisone tapers, the patient is advised to maintain a consistent schedule of treatment. Prevention of Preterm Delivery The relationship between early and prolonged prednisone therapy and preterm birth is more than hypothetical. A number of studies have compared maternal outcomes at the time of delivery, pregnancy outcome, and the use of therapeutic regimens. Preterm delivery remains an issue concerning all types of contraception. In the 1960s, investigators used a randomized, controlled trial to examine the benefits of the use of either 15 mg Prednisone or placebo. In 1967, researchers from the National Institutes of Health (NIH) administered 15 mg Prednisone/placebo, followed by another 15 mg Prednisone before the birth of their second child. A follow-up study, published in 1972, evaluated the outcomes of women who received 15 mg Prednisone as the first, second, or third preterm deliveries, as well as as the use of three other forms of contraception. Among the studies that have been reported, there is little information in regard to the role of prednisone on post-delivery complications. The available data do, however, indicate a potential association between Prednisone treatment and preterm birth, gestational diabetes, and fetal death. Although the studies are lacking in design, the investigators also noted that the results of the latter studies suggested that the risk Similar articles: